| 1 | Dr. G.V.S. Murthi | M.D. (G.M) | 17-08-1946 | 21-07-1947 |
| 2 | Dr. C. Vareed | M.D. (Phy) | 21-07-1947 | 31-12-1948 |
| 3 | Dr. (Mrs.) B. Lazrus | M.S. (Ana) | 01-01-1949 | 02-07-1949 |
| 4 | Dr. K. Govinda Menon | M.S. (Ana) | 13-07-1949 | 05-12-1950 |
| 5 | Dr. D.V. Subba Reddy | M.D. (Phy) | 05-12-1950 | 17-07-1951 |
| 6 | Dr. (Mrs.) Sarah Jsouri | M.S. (Ana) | 19-07-1951 | 22-01-1954 |
| 7 | Dr. V. Sitarama Rao | M.D. (Phar) | 22-01-1954 | 26-07-1954 |
| 8 | Dr. D. Jagannatha Reddy | M.D. (Path) | 26-07-1954 | 21-03-1959 |
| 9 | Dr. S. Venkateswarlu | M.A., MBBS, DMRT, FICS | 22-03-1959 | 23-09-1959 |
| 10 | Dr. D. Jagannatha Reddy | M.D. (Path) | 24-09-1959 | 21-11-1962 |
| 11 | Dr. I. Chalapathinaidu | M.S. (G.S) | 19-02-1963 | 10-07-1964 |
| 12 | Dr. P. Narasimha Rao | M.S., FICS (G.S) | 11-07-1964 | 07-12-1968 |
| 13 | Dr. K. Kodanda Ramaiah | M.D. (G.M) | 30-12-1968 | 11-11-1972 |
| 14 | Dr. (Mrs.) N. Subhadra Devi | M.D. (O&G) | 16-11-1972 | 10-01-1974 |
| 15 | Dr. L. Suryanarayana | M.S. (G.S) | 03-02-1974 | 09-06-1974 |
| 16 | Dr. B. Shanmukheswara Rao | M.S. (G.S) | 10-06-1974 | 30-10-1975 |
| 17 | Dr. D. Bhaskara Reddy | M.D. (Path) | 31-10-1975 | 10-04-1977 |
| 18 | Dr. G. Ethirajuulu | M.S. (Ortho) | 15-04-1977 | 30-11-1978 |
| 19 | Dr. G. Mallikharjuna Rao | M.D. (G.M) I/C | 30-11-1978 | 21-11-1979 |
| 20 | Dr. V. Sathyanarayana Murthy | M.D.(G.M) | 22-11-1979 | 10-04-1980 |
| 21 | Dr. (Mrs.) K. Prasunamba | M.D. (O&G), DGO I/C | 11-04-1980 | 08-08-1980 |
| 22 | Dr. (Mrs.) C. Savithri | M.D. (O&G), D.G.O | 09-08-1980 | 28-02-1983 |
| 23 | Dr. E.N.B. Sarma | M.S. (G.S) | 01-03-1983 | 01-06-1985 |
| 24 | Dr. P. Lakshmana Rao | M.D. | 01-06-1985 | 25-07-1985 |
| 25 | Dr. (Mrs.) C. Savithri | M.D., (O&G), D.G.O | 01-10-1985 | 31-12-1985 |
| 26 | Dr. S. Prema Das | M.D. | 01-01-1986 | 30-04-1986 |
| 27 | Dr. N.V.S. Chowdary | M.S. (G.S) | 06-05-1986 | 24-09-1986 |
| 28 | Dr. G. Sadasivan | M.S. | 24-09-1986 | 25-05-1987 |
| 29 | Dr. K. Krishna Reddy | M.D. I/C | 26-05-1987 | 10-07-1988 |
| 30 | Dr. K. Rajendra Babu | M.S. I/C | 11-07-1988 | 26-09-1991 |
| 31 | Dr. K.S.V.M. Rama Rao | M.D. | 27-09-1991 | 31-10-1991 |
| 32 | Dr. K.C. Hanumanthappa | M.S., D.L.O, I/C | 01-11-1991 | 29-02-1992 |
| 33 | Dr. A. Raghava Rao | M.S. FICS, FIMSA, I/C | 01-03-1992 | 31-07-1992 |
| 34 | Dr. T. Chennamallappa | M.S. I/C | 01-08-1992 | 23-02-1993 |
| 35 | Dr. (Mrs.) G. Venkataramana | M.D. | 24-02-1993 | 08-10-1993 |
| 36 | Dr. K.L.N. Chowdary | M.D. | 09-10-1993 | 31-03-1994 |
| 37 | Dr. P. Venkateswarlu | M.D. | 01-04-1994 | 07-09-1994 |
| 38 | Dr. N.S. Subramanyam | M.S. | 08-09-1994 | 30-09-1994 |
| 39 | Dr. G. Venkat Ramaiah | M.S. | 01-10-1994 | 20-11-1994 |
| 40 | Dr. P. Venkateswarlu | M.D. | 21-11-1994 | 28-02-1995 |
| 41 | Dr. B.N. Sastry | M.D. | 01-03-1995 | 27-06-1995 |
| 42 | Dr. K.M. Lakshmana Rao | M.S. | 28-06-1995 | 31-05-1996 |
| 43 | Dr. (Mrs.) G. Rani | M.D., DCH | 01-06-1996 | 30-11-1997 |
| 44 | Dr. (Mrs.) A. Padmavathi | M.D. | 01-12-1997 | 31-07-1998 |
| 45 | Dr. S. Suryakumari | M.D. | 01-08-1998 | 28-09-1998 |
| 46 | Dr. I. Satyaprasad Rao | MD RT | 29-09-1998 | 31-10-1998 |
| 47 | Dr. S. M. Sirajuddin | M.S. | 01-11-1998 | 10-02-1999 |
| 48 | Dr. S. Suryakumari | M.D. | 01-03-1999 | 30-04-1999 |
| 49 | Dr. V. R. Jayaram | M.D. | 01-05-1999 | 30-09-1999 |
| 50 | Dr. A. Venkataratnam | M.D. | 01-10-1999 | 31-07-2000 |
| 51 | Dr. B. Prabhakaram | M.D. (I/c) | 01-08-2000 | 22-10-2000 |
| 52 | Dr. C. Ramprasad | M.D. | 23-10-2000 | 31-10-2000 |
| 53 | Dr. B. Prabhakaram | M.D. (I/c) | 01-11-2000 | 28-02-2001 |
| 54 | Dr. P. Hymavathi | M.D. | 05-03-2001 | 30-04-2002 |
| 55 | Dr. D. Dattatreya Rao | M.D. | 01-05-2002 | 31-05-2002 |
| 56 | Dr. V. Sivaleela | M.D., D.M.R.F.C.C.A (WHO) | 01-06-2002 | 06-07-2002 |
| 57 | Dr. O. Madhava Kalyani | M.D. | 07-07-2002 | 31-03-2003 |
| 58 | Dr. V. Sivaleela | M.D., D.M.R.F.C.C.A (WHO) | 01-04-2003 | 31-07-2004 |
| 59 | Dr. K. Visweswara Rao | M.D. (Path) | 01-08-2004 | 31-08-2005 |
| 60 | Dr. M. Sobha Mohan | M.D., D.C.H | 01-09-2005 | 18-06-2006 |
| 61 | Dr. K. Umamaheswara Rao | M.D., D.C.H | 19-06-2006 | 04-11-2006 |
| 62 | Dr. K. K. D. Malleswararao | M.D., D,A (I/C) | 05-11-2006 | 07-01-2007 |
| 63 | Dr. K. Umamaheswara Rao | M.D., D.C.H | 08-01-2007 | 30-06-2008 |
| 64 | Dr. A. Venkateswara Rao | M.S. (Opth), D.L.O | 01-07-2008 | 12-08-2008 |
| 65 | Dr. Achyut Rao | M.D. (Micro) | 13-08-2008 | 28-02-2010 |
| 66 | Dr. A. Krishna Rao | M.D. (OBG) | 01-03-2010 | 31-05-2010 |
| 67 | Dr. A. Venkateswara Rao | M.S. (Opth), D.L.O | 01-06-2010 | 31-12-2010 |
| 68 | Dr. K. S. Vara Prasad | M.S., M.Ch | 01-01-2011 | 28-08-2012 |
| 69 | Dr. U. Surya Kumari | M.D., DGO, M.Ch | 29-08-2012 | 20-09-2012 |
| 70 | Dr. K. S. Vara Prasad | M.S., M.Ch | 21-09-2012 | 31-08-2013 |
| 71 | Dr. G. Saila Bala | M.D. (Path) | 01-09-2013 | 28-05-2015 |
| 72 | Dr. P. Mohan Rao | M.D. (Gen Med) | 29-05-2015 | 24-06-2015 |
| 73 | Dr. G. Saila Bala | M.D. (Path) | 25-06-2015 | 31-07-2015 |
| 74 | Dr. D. S. Raju Naidu | M.D., D.M.R.T | 01-08-2015 | 24-09-2015 |
| 75 | Dr. G. Subba Rao | M.S. (G.S) | 25-09-2015 | 02-06-2020 |
| 76 | Dr. S. Babu Lal | M.D. (Pulm) | 03-06-2020 | 31-07-2021 |
| 77 | Dr. C. Padmavathi Devi | M.D., DCP (Path) | 01-08-2021 | 01-04-2022 |
| 78 | Dr. C. Padmavathi Devi | M.D., DCP (Path) (Addl. Director ME) | 02-04-2022 | 31-03-2023 |
| 79 | Dr. N. Uma Jyothi | M.D. (Psych) | 01-04-2023 | 21-09-2023 |
| 80 | Dr. K. Jeevan Pradeep | M.S., DLO | 22-09-2023 | 30-09-2023 |
| 81 | Dr. T. T. K. Reddy | M.D. | 01-10-2023 | 31-10-2024 |
| 82 | Dr. N. V. Sundara Chary | M.D., D.M (Neuro), SCE (Neuro), FAAN, M.Sc (SPSYC) | 01-11-2024 | Present |
